The increasing use of aluminum alloys (6061-T6) in shipbuilding, aeronautics, marine frames, railway vehicles, bridges, offshore structure topsides, and automobile industry relevance due to its light weight and high strength to weight ratio. The present investigation is designed to study the effect of various process parameters (welding current, voltage, and angle of the torch.) in metal inert gas (MIG) welding processes on a bead on the plate of aluminum alloy 6061-T6. In this alloy, the weld fusion zone has coarse columnar grains because of the unequal heat distribution during weld metal solidification. Electrode material has selected for MIG welding as ER4043. Taguchi’s optimization technique and orthogonal array matrix were used to optimize and selection of the process parameters for better results.