Pre-eclampsia(PE) complicates 2–8% of pregnancies globally, and 9% of maternal deaths are attributed to pre-eclampsia in Africa and Asia 1. The study objective is to evaluate the efficacy of the Capacity Building Programme in Predicting Preeclampsia using Glycosylated Fibronectin as a Point of Care Biomarker (GlyFn POC) among Staff Nurses. Methodology: A pre-experimental design was conducted among 40 staff nurses selected through consecutive sampling techniques at selected hospitals in Chennai. Pretest was conducted using background variables proforma, a Structured questionnaire on predicting preeclampsia by using (GlyFn POC), a checklist to assess the competency on (GlyFn POC) and a rating scale for the level of acceptability on the capacity building programme. The capacity building programme was conducted by lecture cum discussion and demonstration method for 2 hours. Post-test was done one week after the intervention, and knowledge and skills were assessed using the same tool. Results: The mean posttest knowledge scores on (GlyFn POC) were higher (21.87 + 3.87) than the pretest knowledge scores (17.32 + 3.45), significant at p <0.0001. Most of the staff Nurses acquired moderately adequate skills, 65%, in performing tests with the (GlyFn POC) to Predict Preeclampsia. Conclusion: Thus, the training program of the health care provider on the updated test helps them to predict preeclampsia at the earliest and protects the pregnant women from complications