Each year about 2.2 million people develop TB in India and an estimated 220,000 die from the disease. According to the World Health Organization (WHO), it’s the most deadly infectious disease in the world, killing 1.5 million people in 2014. TB is most common in developing countries. Tuberculosis is usually preventable and curable under the right conditions. To assess the effectiveness of the nurse-led intervention on Quality of Life (QoL) among patients with tuberculosis. A Quasi-experimental study with time series design with a comparison group was conducted in two selected Hospitals of Kanpur 50 active tuberculosis patients( 25 experimental and 25 in the comparison group) formed the sample for the study The researcher used structured questionnaire to elicit demographic data and WHO QoL BREF scale to assess Quality of life. The nurse-led interventions were individualized teaching on tuberculosis to patients and family education in the prevention and management of tuberculosis. To experimental group the comparison group followed ward routine, The post-intervention and assessment of the quality of life were done at 15 days and 60 days for both the group. There was a significant difference in the quality of life in 15 days and 60 days at p.<001 level The Mean difference was high in all domains of quality of life in the experimental group except physical domain. The highest mean difference in QoL was found in environmental health and the lowest in physical domain with 95% Cl after an intervention that infers the nurse-led intervention was effective whereas the Mean difference in all domains in the comparison group was very low. The Association of pre-intervention level of QOL among subjects with their selected clinical characteristics in the comparison group showed that extension of tuberculosis and the zone affected by tuberculosis in the social domain and symptoms of tuberculosis in environmental Te domain is influenced at p <0.05 level of significance There was no significant association of QoL with demographic variables. The intervention was effective in improving QoL among Tuberculosis patients.