Stress is a common phenomenon among most individuals today and can be related to education, job, relationship, financial and other pressures. Stress is experienced by every human being irrespective of age, sex or nationality. A pre-experimental study was conducted to assess the effectiveness of the Positive Behavior Therapy upon Stress among fifty Nursing students at selected Nursing College, Chennai. Fifty Nursing students were selected using purposive sampling technique. Data was collected using Demographic Variable Proforma and Stress questionnaire among selected Nursing students through self-administrative method. A rating scale was used to assess the level of satisfaction of Nursing students regarding Positive Behavior Therapy. Positive Behavior Therapy was administered to reduce stress among Nursing students. Results: Study findings revealed that obtained post-test mean value 35 ± 10.8 was lower than pre-test mean value 44.5± 9.5 (P<0.001). Conclusion: Positive Behavior Therapy was effective in reducing stress among Nursing students.