Zandu Universal Oil is a topical ayurvedic formulation comprising active ingredients such as Mentha sp., Gaultheria fragrantissima, Cinnamomum camphora, Eucalyptus globulus, Melaleuca leucadendron, Elettaria cardamomum oil, and Capsicum annuum in a base (q.s.). This study aims to evaluate the efficacy of this over-the-counter (OTC) product for relieving symptoms of cold and pain. A prospective, open-label, phase 4 study was conducted with consenting adults (n=30) who were experiencing cold-related symptoms. Each participant received one bottle of the product to use over a 6-day period and provided feedback on its effectiveness using a visual analogue scale. Efficacy scores were recorded on days 0, 2, 4, and 6. Results showed significant relief from cold and nasal congestion within 2 days, and a reduction in headache and body pain ( measured as backache) associated with cold by day 6 (p <0.001). Conclusion: Zandu Universal Oil is an effective remedy for alleviating cold symptoms and associated discomfort.