Now a day energy is a fundamental need of everyone and saving of energy is main aim of an engineer. So more practical emphasis work should be carried out on main two approaches, to save the energy and keep the environment clean and human comfort is also a fundamental need in the present scenario. In this research work we are dealing with change in load due to the different orientation of a multistory building at same latitude of the location. For our analysis purpose we are considering Mechanical Department building of MGITER (latitude- 20.9079oN) which is situated at Navsari in Gujarat as a case study. From this research work we have concluded that the building at 0o is the optimal condition as per the orientation which saves about 3-4% economically from the other orientation