Sandhigata Vata is described under Vatavyadhi in Samhitas and Sangraha texts. Sushrutha has included Vata vyadi as one among the Ashta Mahagada, which is a Yapya vyadhi. In Vriddhvastha all the dhatus undergo Kshaya. Thus it leads to Vataprakopa and makes individuals prone to many diseases especially affecting the joints. Based on the symptoms, it can be compared with Osteoarthritis of Knee according to modern science. Osteoarthritis is also known as degenerative arthritis that results from the breakdown of joint cartilage. Its prevalence is more in female and among old age people. It mainly affected weight-bearing joints of the body especially the knee, hip, lumbar spine associated with ageing, physical occupation, activity, and obesity. In Ayurveda Shoola, Sotha and difficult in flexion and extension of the Sandhi (Prasarana Aankuchan Pravriti Vedana)are the symptoms. These groups of symptoms have been described as Sandhigata Vata by various acharyas. In the present study, the diagnosed cases of Sandhigata vata were treated with traditional Ayurvedic oral medicines along with local application of medicated oil and Jambira pinda i swedana as a special therapy. The result showed that Ayurvedic treatment procedures are significant in the Sandhigata vata without any ADR. The result of the present study revealed the therapeutic use of the natural product according to Ayurvedic principle and practice of Sandhigata vata. The improvement of the present Ayurvedic treatment procedure on pain 60.70%, stiffness 68.44%, restricted movement 62.30%, crepitations m 54.60% and tenderness77.66%. The overall relief was observed 64.74%.