In day-to-day life, our skin is exposed to various chemicals, environmental pollution, and UV radiation which results in the early onset of photoaging and skin darkening. There is increased demand for skin whitening cosmetics for skin protection as well as aesthetic looks. The current skin whitening agents used in cosmetic industries have adverse effects on the skin. There is increased demand for natural active agents as a skin whitening agent. Cyanobacteria are ubiquitous in nature and quickly adopt different environments.1 Alga produce various secondary metabolites like carotenoids, phenolics, flavonoids, MAA (mycosporine-like amino acids) which are antioxidants in nature and have therapeutic potential in the pharmaceutical and cosmetic industry2. This study focuses on the isolation and characterization of cyanobacteria from different environmental niches. The antioxidant potential of whole-cell extracts of cyanobacteria was evaluated using DPPH inhibition assay and ABTS assay. Their potential application as a skin whitening agent was studied by anti-tyrosinase activity using the mushroom tyrosinase enzyme. The tyrosinase inhibition activity of cyanobacterial isolates was observed in the range of 30 to 40%. They have good antioxidant potential. They are rich in carbohydrate, protein, and lipid content indicate the potential of the cyanobacterial extracts so they have potential in the cosmetic and pharmaceutical industries.