White spot lesions are often seen on the teeth after orthodontic treatment, resulting in unpleasant esthetics. Despite many attempts at prevention of white spot lesions, its prevalence remains very high on debonding. The aim of the study was to evaluate the efficiency of 3 commercially available toothpaste/creams in the remineralization of white spot lesions. Materials and Methods: Hundred extracted premolars were selected as sample teeth. They were mounted into an acrylic resin block and randomly divided into four groups, consisting of 25 teeth each. Premolar brackets were bonded to facial surfaces. The specimens were color-coded with Yellow (Group-1), Red (Group-2), Green (Group-3) and Blue (Group-4). Sample teeth were exposed to demineralization solution for 14 days to produce white spot lesion. Visual verification of white spot lesions was done after 14 days on all sample teeth and brackets were debonded. The comparison between 4 groups: Artificial saliva (Group 1), Colgate PreviDent 5000 toothpaste (Group 2), GC Tooth mousse tooth crème (Group 3), Clinpro tooth crème (Group 4), were done at pre-treatment, 14-days after demineralization, 7-days after treatment, 14-days after treatment, 21-days after treatment and 28-days after treatment using Gloss meter and Surface Profilometer instrument. Results: The mean 28 days after treatment Gloss meter values for Group 1 (Artificial saliva) were 20.69±2.41 GU, for Group 2 (PreviDent 5000 toothpaste) were 21.70±2.06 GU, for Group 3 (Tooth mousse tooth crème) were 23.59±2.40 GU and for Group 4 (Clinpro tooth crème) were 22.56±2.98 GU respectively. And mean 28 days after treatment Profilometer values for Group 1 (Artificial saliva) were 1.84 ± 0.50µm, for Group 2 (PreviDent 5000 toothpaste) were 1.542 ± 0.33µm, for Group 3 (Tooth mousse tooth crème) were 1.254 ± 0.08µm and for Group 4 (Clinpro tooth crème) were 1.475 ± 0.20µm respectively. Conclusion: The result of the study indicated that Gc Tooth mousse tooth crème, PreviDent 5000 toothpaste, and Clinpro tooth crème have higher remineralization potential compared to Artificial saliva. Gc tooth mouse crème had the highest remineralization potential followed by Clinpro tooth crème and PreviDent 5000 in both Gloss meter test and Profilometer test. The increased efficiency of Tooth Mousse in remineralizing white spot lesion might be because of the combined effect of CPP –APP and fluoride which was not there in all other groups.