OSAS has become a significant public health problem with the increasing demands of modern society. It is often associated with serious and adverse consequences as it is most of the time associated with comorbid conditions. Objectives of this paper are: To assess the impact of OSAS with and without comorbidities on Quality of life in either gender of different age The sample of 205 patients diagnosed as having OSAS was divided into two groups depending on the presence and absence of comorbid conditions. OSAS patients with comorbidities were 179 and 26 patients were without comorbidities. The patients were administered with the specific evaluation scale SAQLI. In Group with Comorbidities- Quality of life (SAQLI) of patients was strongly affected by the degree of apnea severity and age. Gender comparison revealed more affection in females in domains Daily functioning, Social interactions, Emotional function. In Group without Comorbidities- Quality of life (SAQLI) of patients was strongly affected by the degree of apnea severity however, no correlation was observed gender and age wise in patients without comorbidities. Conclusion: The impact of OSAS in patients without comorbidities was significantly less than in patients with comorbidities.