Fat Embolic Syndrome is a serious and life threatening condition. It occurs most frequently after fractures of long bones particularly the femur and tibia or intramedullary instrumentation for such bone fractures management. Some non-traumatic conditions such as diabetes mellitus, severe Burns, SLE and pancreatitis etc. can also result in Fat Embolic Syndrome. Young adults irrespective of sex are commonly affected. Its classical presentation consists of an asymptomatic interval following injury followed by pulmonary and neurological manifestations combined with petechial hemorrhages over the upper chest and axillae. The management of such cases needs to have high index of suspicions and aggressive approach to combat the condition with exclusion of other conditions. As this dreadful condition is a self-limiting one, the treatment of this condition remains mainly supervised supportive to the most affected organ system mainly pulmonary and cardiac. Mortality related to this condition is critical, starting from 10-20 %. Here is a description of such a fatal case managed well and the outcome was rewarding.