In-home health care services based on the Internet-of-Things (IoT) have great business potential. In this paper, an intelligent home-based platform, the Health-IoT, is proposed and implemented. In particular, the platform involves an open-platform-based intelligent medicine box (Med-Box) with enhanced connectivity and interchangeability for the integration of devices and services. Flexible and wearable bio-medical sensor like heart rate and temperature, ECG sensor etc are incorporated in this. The proposed platform seamlessly fuses IoT devices with in-home healthcare. Services for an improved user experience and service efficiency. The feasibility of the implemented Health-IoT platform has been proven in field trials. Medicine box and the wearable sensors are connected to Server via an Android-based smartphone through Bluetooth, which has an interface for the patient to see his medicine conception and health status the remotely connected web page is operated from hospital which has provision for giving the prescription and view all patients consultation details and test details consulted doctors etc. The Medicine conception details and alert are given to mobile app via this website with is connected through the internet, If the patient forgot to take medicine or take a wrong one which can be alerted through the app. And here discussed how to implement in a real-world system. Analyze system capacity by testing devices and modules.