The present study is aimed to evaluate hepatoprotective and antioxidant activity of Acalypha indica L. methanolic on the Ethanol induced hepatotoxicity. Material and method: Hepatotoxicity was induced by Ethanol 40%v/v (0.4ml/kg b.wt) for 25days. Methanolic extract of Acalypha indica at different doses (100 and 300 mg/kg b.wt.) were administered to male Wistar rats weighing between 150 and 200 g from 26 to 50 days. Then activity of Acalypha indica against Ethanol was compared with Silymarin (100 mg/kg b.wt). Biochemical parameters like serum SGPT, SGOT, ALP and total Bilirubin and levels of anti-oxidants were estimated to assess the liver function. Histopathological changes were assessed using H&E staining. Results: Phytochemical analysis showed that methanolic extract of Acalypha indica contains poly phenolic compounds, tannins, flavanoids, alkaloids and saponins. Acute toxicity study shows that methanolic extract was safe up to 2000 mg/kg body weight. The toxicant induced a rise in the plasma enzyme levels of ALT, SGOT, SGPT and total Bilirubin level and oxidative stress. This increased level was significantly lowered by the extract at 300 mg/kg bw than 100 mg/kg bw. The Histopathological changes showed recovery in animals treated with the extract. Conclusion: The finding suggests there was significant reduction in elevated levels of serum enzymes and oxidative stress levels . From the above it is found that Acalypha indica extract in curative study exhibit a marked hepatoprotective activity. This shows the addition of this plant in the management of liver disorders.