The most important aspect of pharmaceuticals is its safety and efficacy which determines the fundamental aspect of its drug therapy. Therefore controlling the levels of impurities in drugs is important. There are many different types of impurities that are present in pharmaceuticals, in this study the focus is on inorganic impurities and the analytical techniques used for its detection mainly ICP-MS, ICP-OES. These new methods address the limitations of the current methods like ‘heavy metal tests’, extending the list of analytes, reducing maximum permitted exposure limits and taking account of the route of exposure. In this study, we found that ICP-MS is an effective tool in impurity profiling of Single, Multi and speciation analysis of different element's present in bulk drugs and formulations. In recent scenario, many of the pharmaceutical industries are adopting these hyphenated techniques.