Purpose: The paper analyzes the psychological state of patients with congenital heart diseases as related to age and gender.  The aim of the study is to analyze the perspective of adolescents on the psychological aspect on a gender basis.  The study was initiated to compare the gender attitude among adolescents (age 13-18 years), who can lead a normal life after corrective surgery/treatment. Methods: The data was collected from two reputed hospitals of Delhi, having paediatric cardiology department running for almost more than 10 years.  A Questionnaire from PCQLI was used to collect data, with their permission.  The questionnaire is already valid and reliable. The study was conducted, with permission from hospital authorities.  A sample of around 30 patients was collected to study the quality of life aspect using various psychological parameters.  An independent sample t-test was applied to compare the perspective of two groups. Findings: The result was analyzed between the perspective difference between male and female population on the psychological aspect.  The data showed some psychological variables reflect the significant difference between male and female but some variables do not reflect any difference. Recommendation: The findings from the study indicate a need to peep into psychological aspect of patients with congenital heart disease, so that they can be helped to better manage their health prospective in future.