The optimal route from the source node to the destination node that guarantees a high end-to-end throughput is the main issue of routing in multi-hop wireless network. As the environment is heterogeneous the issue seems to be much complex, most of the solutions end with local optimum because those algorithms mostly fail to ensure an end to end throughput. By considering spatial reusability of wireless media, the end-to-end throughput in wireless multi-hop remote systems can be enhanced massively. To support the argument, Spatial-reusability Aware Single-path Routing (SASR) algorithm is proposed and compared with existing single path routing protocol. The assessment showed that proposed protocol show significant improvement in end-to-end throughput in comparison with existing protocols.