In an effort to determine the water quality of Narmada River flowing from Moretakka, National Sanitation Foundation water quality index was selected in this piece of work. In support of the work, indexing of River water collected from centre and both left and right catchment areas was conducted between September 2010 and September 2012. The National Sanitation Foundation (NSF) Water Quality Index (WQI) was one of the analytical tools used to summarize the data. Essentially, the WQI converts the concentration data for nine analytes into one of five water quality classes, ranging from “very bad to excellent”. Based on the WQI values, water quality typically was in the “good” range for the year 2010-11, while its range decreases to “medium” in the following year 2011-12. The sites nearest the centre had the highest water quality rating with significant decreases in water quality occurring in the catchment area, particularly in Left catchment area. Water quality also was significantly impacted by socio biological activities. High total coliform levels (>1600 microorganisms/100 ml) are of particular concern for all the sampling sites.