Kafe Darya (cuttlefish bone) is one of the most important animal-origin drugs used in the Unani system of medicine for various disorders. It is used as an ingredient in various unani formulations. Over 200 animal-origin drugs are used in the Unani system for treating various ailments, and ‘kafe dariya’ is one of the most important among them. There are five to six types of ‘kafe dariya,’ each with different properties and uses. ‘Kafe dariya’ is used externally to treat skin inflammation, anti-inflammatory (muhalil), pigmentation, and other skin diseases such as ringworms and scabies. It is also used internally for treating headaches, insomnia, gonorrhoea, and renal calculi (mufttihwamukhrijehasa). ‘Kafe dariya’ is rich in calcium and other bioinorganic elements such as magnesium, strontium, iron, and trace amounts of copper and zinc, making it an excellent source of these nutrients.