Lantana camara is considered to be a voracious and poisonous weed, as it spreads rapidly and chocks the native vegetation, spoils animal habitats, biodiversity, leads to shortage of fodder for herbivores, and exerts toxic effects when ingested by livestock, hence L. camara is regularly eradicated by the villagers.The present study was carried out to assses the Hazardous effect of Lantana camara on soil microflora. It is clear from results that Lantana camara possess adverse effect on soil microflora & thereby decreases fertility of nearby soil. The bare land development is final cause of growth of Lantana camara plant on waste / agriculture land . As we know presence of microbial population and their activity in soil is directly proportional to the fertility of soil. In cities & villages Lantana camara is growing in uncontrolled way on waste land and so that it also affect agriculture land via seed migration , resultate into the decrease in soil fertility of agriculture land. On the basis of our study we can suggest that Lantana camara plant growth should be controlled in village,cities & in agriculture land. However, present study advocates its uses by pharmaceutical industries for preparing plant-based antimicrobials drugs in addition to fungal nanoparticles, rather than to throw the eradicated plants as garbage.