Type 2 diabetes patients will have a higher incidence of abnormal liver enzymes than individuals who do not have diabetes Aminotransferases, such as alanine aminotransferase and aspartate aminotransferase serve as a marker of hepatocyte injury. Alkaline phosphatase, γ-glutamyl transpeptidase, and bilirubin act as markers of biliary function and cholestasis. Albumin and prothrombin reflect liver synthetic function. The aim of our study was to assess the profile of liver enzymes in subjects with T2DM. Materials and methods: It is a cross-sectional study, where 100 Type 2 diabetes patients attending the Medical OP, NRI General Hospital aged between 40 – 69 yrs were included in the study. The blood sample was collected from all the patients to analyze FPG, PPPG and liver enzymes. The data were analyzed and presented as means ± SD. Statistical analyses were done using t-tests, Pearson’s correlation. P < 0.05 was considered significant. Results: In 47% of Type 2 diabetes patient’s elevated liver enzymes were seen. Mean levels of liver enzymes were higher in men than those in women (26.0 ± 24.8 vs. 21.4 ± 16.0 IU/l in AST, 32.8 ± 20.1 vs. 26.3 ± 13.1 IU/l in ALT), but in ALP, bilirubin and albumin levels there is no mean elevation and no significant difference between male and female. Conclusion: In this study, we found the highest incidence of mildly elevated transaminases in Type 2 diabetes patients. Increased activity of liver enzymes, particularly ALT was associated with an increase in developing insulin resistance and further makes diabetes worsen. So, the estimation of liver enzymes in Type 2 diabetes patients may be helpful in treatment process.