To critically evaluate the effect of silver diamine fluoride (SDF) on the bacterial load of cariogenic bacteria in children. Electronic databases were searched from Google Scholar, PubMed, Wiley online library, SciELO, Science Direct, Scopus, Cochrane from 2013 till the 15th of August 2020 to list out studies undertaken to evaluate the effect of silver diamine fluoride on cariogenic bacteria in children from 2 to 10 years. Abstracts and subsequently eligible full-text articles were screened. Results: Six hundred sixty-five studies were obtained from all the databases. After a thorough screening, five studies met all the inclusion criteria. Four studies assessed the bacterial load with the microbiological culture method, two studies assessed bacteria with Adenosine triphosphate (ATP) bio-luminometer. Conclusion: Peak antimicrobial action of SDF was appreciated from the 3rd -30th day of post-application.