Keratin is a major complex structural protein present in hair, wool, home, hoops, feathers and nails of animals. It is considered as an environmental pollutant because of its slow degradation and produced mostly at both domestic and industrial levels. So beneficial utilisation and management go these keratin based waste has a significant importance. Out of many traditional and new approaches to breakdown keratin, the use of natural soil keratinophilic microbes is widely studied because of nontoxic and useful byproducts produced. These keratin based products have a widespread application in medical, animal feed, fertiliser, biomedical uses and many other type of industries. In the present review various strategies for hydrolysis of keratin from the organic waste have been described and use of natural keratin in different industries have also been explored.