Manilkara zapota, also known as Sapodilla, is very commonly distributed in the Indian subcontinent. It is an important member of Sapotaceae family as it is well known all over the world for its traditional medicinal uses. Numerous phytoconstituents have been reported from the plant by different authors that are responsible for many biological effects such as anti-inflammatory, anti-arthritis, anti-bacterial, anti-fungal, anti-oxidant, anti-tumor and anti-diabetic activities. The present article describes a detailed review of literature for this plant species including taxonomy, pharmacology, and phytochemistry in an organized way. This review paper will surely serve as an important source for the future scientific investigations on this plant.