The route of administration for a drug should be particular to attain a useful concentration at the site of action as suitably as possible. Important subsidiary objectives may be rapidity of onset and duration of drug effect and, in some instances, the selectivity of action. The route of administration is the method through which the dosage form is administered into the body for the treatment of various diseases and disorders. Various routes of administrations play a clear role in the bioavailability of the active drug in the body. In the current review, these routes are integrated with their advantages and limitations. This is an attempt for the initials of the field to bring into the light with the routes of administrations with their significances. Many drugs will elicit effects of similar magnitudes when the same dose is given by a number of different routes. However, there are so many instances when this is not true that these can be important traps for the unwary pharmacologist, toxicologist, or clinician. Several drugs with effects that vary according to the route of administration.