Plasma, the fourth state of matter, is slowly making its way into the pharmaceutical business and medicine. It's already being used in a variety of applications, including causing apoptosis, necrosis, and cell detachment, as well as in the form of CAP (cold atmospheric plasma) and Jett plasma (used for skincare). It is unquestionably regarded as a major and potentially useful tool in the future of medicine. Plasma is essentially an ionized gas, and the plasma sources employed in plasma medicine are mainly ‘low temperature' plasma sources that operate at atmospheric pressure. It eliminates reactive species and can be used on cells and tissues without causing heat damage. It eliminates reactive species and can be used on cells and tissues without causing heat damage. Low temperature is defined here as room temperature, with a tight upper limit of 50 degrees Celsius. The overall goal of this article is to provide an understanding of how much plasma that has been ionized gas can be used to cure a variety of diseases and pathological situations with minimal adverse effects. Also, to provide information about its development history, current use, and prospective future. To raise awareness that this is being thoroughly examined by research groups all over the world as part of the extremely interdisciplinary subject of 'plasma medicine.