The present study was conducted to develop nano CoQ10 capsule. The experiment was designed accordingly ZEON F&D SOP for the nano CoQ10 Capsule ZLL/F&D/041. Six formulations were carried for development of nano CoQ10 capsule to check the overall acceptability. For the development of nano CoQ10 capsule, experimental design with the active ingredient (nano CoQ10 powder), lubricant, glidant, diluents and disintegrant produced different combinations that were studied using pre and post evaluation parameters. The methodology of nano CoQ₁₀ was carried out by dry mixing method. Capsule filling was performed by using hand capsule filling machine. Nano CoQ₁₀  was the main factor of the capsule , nano increase the bioavailability of CoQ₁₀  which possess significant role in various disease like, cardiac failure, ischemic heart disease, interaction with statins, hypertension, diabetes, neurodegenerative diseases, Parkinson's disease, Huntington's disease, Alzheimer's disease, cancer, aging, Down's syndrome, Periodontal Disease etc.