Advancements in nanotechnology have led to numerous potential applications in dentistry, with nanomaterials becoming increasingly significant in endodontics.1 Nanosized particles, like clusters of small numbers of atoms or molecules in nanostructured biomaterials, have shown significantly superior properties in biomedical research compared to the same materials at larger scales of measurement.2 These unique mechanical and chemical properties help nanomaterials to have various applications in endodontics such as obturating materials, sealers, antimicrobials, retro-filling materials, root repair and regeneration. The improved antimicrobial property of the nanomaterials is helpful in eradicating bacterial load in the canals which can be incorporated in the form of irrigants and medicaments. Applications in regenerative endodontics are currently underway creating improved scaffolds and growth-factor delivery.2 This review throws insights on the current knowledge and scientific applications of nanomaterials in the field of endodontics as well as its potential future scope.