Neutrophils are highly versatile and sophisticated cells which act as the body’s first line of defence. They act as effectors in both innate and adaptive immunoregulatory networks. Neutrophil extracellular traps are a new and unexpected antimicrobial activity of neutrophils wherein upon encountering bacteria, neutrophils release a meshlike structure capable of ensnaring and eliminating microbes. Studies have shown that periodontitis is characterized by neutrophil infiltration and the formation of Neutrophil Extracellular Traps (NETs). This review is intended to highlight the structure and formation of NET, NETosis, NET in health and disease and the role of NET production in periodontal pathophysiology.