In recent years, numerous research articles have been published relating to the potential of niosomes to serve as a biodegradable, biocompatible carrier for the delivery of various types of drugs. Niosomes are vesicles that are mostly composed of synthetic surfactants and cholesterol. The vesicular system of niosomes, with its bilayer structure assembled by nonionic surfactants, can increase the bioavailability of a drug to a specific area for a set period of time. Niosomes' amphiphilic nature enhances their ability to encapsulate lipophilic or hydrophilic drugs. Other additives, such as cholesterol, can be used to keep the structure of the niosomes rigid. The efficient use can be defined as a lower dose, fewer side effects, fewer dosages, greater patient compliance, and maximum concentration of the drug at the site of action to reduce unnecessary exposure to the entire body. This narrative review discusses the fundamentals of niosomes, such as their structural components and methods