The study of this investigation is the comparison of CFD Analysis of ZnO & TiO2 Nano-Fluid with Oil and Ethylene Glycol as a base fluid in Tapered Helical Coil Heat Exchanger with the help of CFD on the copper tube. The Zinc Oxide(ZnO) & Titanium Oxide (TiO2), are used as Nanofluid and water and ethylene glycol is a base fluid. Tapered Helical coil was fabricated by bending 500 mm length of a copper tube having 10mm tube diameter, 50mm pitch coil diameter, 20mm pitch and Square shaped coil was fabricated by bending 500 mm length of a copper tube having 10mm square side, 50mm pitch coil dia, 20 mm pitch. The comparison of pressure drop and temperature variation between ZnO & TiO2 nanofluid with oil as its base and ZnO & TiO2 nanofluid with ethylene glycol as its base is found in this analysis. The result indicates that the ZnO nanofluid with oil as a base fluid has maximum pressure drop and also has maximum temperature variation compared with other nanofluid and base fluid as a base fluid. A computational fluid dynamics (CFD) methodology using ANSYS FLUENT 15 is used here to investigate pressure drop of Zinc Oxide (ZnO) & Titanium Oxide (TiO2) nanofluid with ethylene glycol and water as its base fluid on the heat transfer characteristics in a tapered helically coil-tube.