The growing demand for products that resist environments considered severe has stimulated in the last year's series of research. They have the objective to improve the properties of materials and their processing and applications. Among the metals commonly used in extreme temperature and corrosion, there are nickel superalloys. However, the same thermal, mechanical, and metallurgical properties, which make it a material of great applicability, are also characterized as one of the metals of low machinability. Given that the market trend is increasingly using special materials such as superalloys, a detailed study about the machining of these materials is strategic and it is necessary that companies constantly seek to improve their processes. Besides that, the attention to environmentally safe processes from society and governmental regulation is growing. Therefore, this paper evaluates the economic machinability of superalloy Inconel 625 round bar on a CNC turning Lathe machine as Inconel 625 material has many industrial applications. In this work Taguchi’s DOE L9 orthogonal array was employed with the aim of simultaneously optimizing surface hardness, cutting force with tooling cost, and cutting time incorporated. Cutting speed, feed rate, and depth of cut were chosen as process control factors.