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Research Paper

Development and validation of UV-spectrophotometric methods for simultaneous estimation of chlorzoxazone and tramadol in laboratory mixture

The present manuscript describes a simple, sensitive, rapid, accurate, precise, and economical Simultaneous equation method and first-order derivative spectrophotometry method for the simultaneous determination of Chlorzoxazone and Tramadol in laboratory mixture. The absorbance values at 243.3 nm and 271 nm for the simultaneous equation method and 236.6nm and 213.3nm for the first derivative spectrum were used for the estimation of Chlorzoxazone and Tramadol. This method obeyed beer’s law in the concentration range of 2-10 μg/ml for Chlorzoxazone and 10-100 μg/ml for Tramadol. The solvents used for UV-Spectrophotometric methods was 0.1 N NaOH. The % RSD of accuracy was found to be 0.2086 for Chlorzoxazone and 0.4717 for Tramadol. The method was successfully applied to the laboratory prepared mixture because no interference from the mixture excipients was found. The suitability of this method for the quantitative determination of Chlorzoxazone and Tramadol was proved by validation. The results of analysis have been validated statistically and by recovery studies.

Published by: Rushika Jaiswal

Author: Rushika Jaiswal

Paper ID: V6I3-1678

Paper Status: published

Published: July 3, 2020

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Research Paper

Indian Diaspora

It is globally accepted fact that Diasporic writers set a trend since the Independence. Indian Diaspora occupies the second largest place in the world. The population of Diaspora is approximately 25 million, who settled in the whole notable regions of the world. Diasporic literature irrespective of languages, style, literary form and technique attract the readers crossing the borders. It may be stream of consciousness or magic realism or immigrancy of a new land and culture. But nostalgia is all Diaspora writers. It is an Interesting Paradox that a great deal of Indian writing in English is produced not in India but in widely distributed geographical areas.

Published by: Rekha Mahadev

Author: Rekha Mahadev

Paper ID: V6I3-1667

Paper Status: published

Published: July 3, 2020

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Review Paper

A review on Bacteriophages: Our saviour and weapon for post-antibiotic world

The rate of Emergence of antibiotic-resistant bacteria has become exponential in recent times due to the irrational exploitation of antibiotics. If this trend continues, the world and human civilization as we know it would be pushed back to the dark pre-antibiotic age. Bacteriophages could hold the key to abate the antibiotic crisis. Bacteriophages are the viruses that specifically infect and kill prokaryotic bacteria sparing human eukaryotic cells and also has a limited effect on the human microbiome this dogma makes them suitable candidates to replace antibiotics in the near future. Bacteriophages, by using a novel mechanism than the conventional antibiotics would empower us to treat drug-resistant bacterial infections, they can also be used along with antibiotics to give a maximum effect to terminate bacterial infections. Phage therapy was already in use before the discovery of antibiotics however, discovery and development of antibiotics dampened their progress in modern therapeutics. In the current scenario, it seems vital to reinvent and reestablish phage therapy and employ them to treat infections by superbugs. Plenty of groundbreaking research has been done in the past few years regarding the usage of phages in modern therapeutics. Bacteriophages, if studied properly, has the potential to supplement or even substitute antibiotics. This review will provide information on the lytic mechanism of phages, summaries of successful research done by using phage therapy against bacteria in the animal model, and current human trials along with synergism between antibiotics and phages. Some of the key aspects of synthetic or bioengineered phages and their uses are also incorporated. Finally, a discussion on solutions for carving a path for the successful employment of phage therapy in the future is inserted.

Published by: Saif Ali Nasir Surti

Author: Saif Ali Nasir Surti

Paper ID: V6I3-1649

Paper Status: published

Published: July 3, 2020

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Survey Report

Heuristics and Meta-Heuristics optimization methods in solving Traveling Salesman Problem TSP

In modern societies there are increasingly more often problems of various kinds, and tests are needed to solve them in experimental ways. Although, Develop a mathematical model that closely matches the reality to solve a real life problem is very complicated, since many of these models might has to contain very large number of variables (as a heuristic model that optimizes problems solving results). Furthermore, these shows as difficult problems in controlling subjective behaviours, so They are making it even more complicated than these models resemble reality (wrong solving model leads to a more complex level). The purpose of this research is the study of combinatorial optimization problems using approximate methods. In particular, this work focuses on the analysis of meta-heuristics algorithms based on history and population related to the solution of Travelling Salesman Problem (TSP) like Particle Swarm Optimization (PSO), Ant Colony Optimization (ACO), Simulated Annealing (SA) and many others, as well as hybrids, which allow efficiently to solve generic problems.

Published by: Jawaher A. Al-Ghamdi, Eyad R Al-Masalmeh

Author: Jawaher A. Al-Ghamdi

Paper ID: V6I3-1427

Paper Status: published

Published: July 2, 2020

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Dissertations

Study of the toxicity of two pharmaceuticals on invertebrate Hydra Vulgaris and observing effects on morphology and physiology

The Cnidarian Hydra has been extensively used as a model organism studying the teratogenic and toxic potential of numerous toxins throughout the years and are more recently growing in popularity to assess the impacts of environmental pollutants. Hydra is an appropriate bioindicator species for use in environmental assessment owing to their easily measurable physical (morphology), biochemical (xenobiotic biotransformation; oxidative stress), behavioural (feeding) and reproductive (sexual and asexual) endpoints. Pharmaceuticals enter natural waters through sewage effluent and landfills and present an unknown risk to aquatic species including freshwater invertebrates. The cnidarian Hydra has been widely used to assess the acute toxicity of freshwater pollutants, but very little is known about pollutant accumulation by this animal. This study was conducted to study the effect of commonly used drugs, Paracetamol and Acetylsalicylic acid (Aspirin) on the morphological and physiological working of Hydra Vulgaris. The Hydra was exposed to 4 different concentrations of each drug for 24 hours and then observed for morphological and physiological changes.

Published by: Khyati Joshi

Author: Khyati Joshi

Paper ID: V6I3-1661

Paper Status: published

Published: July 2, 2020

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Research Paper

Development and shelf-life studies of pea enriched gluten free cookies

Millets are gluten free and excellent for celiac disease patients. An attempt was made to develop pea incorporated millet cookies. The developed cookies were analyzed for physical parameters like weight, thickness, and diameter, spread ratio, percent spread and bulk density. The cookies were analyzed for proximate composition, mineral content, anti-nutrients and anti-oxidants. The products were packed in polyethylene pouches and stored at ambient temperature for 4months and analyzed for microbial and consumer acceptability. On storage there was increase in the moisture content of the samples from 4.65% to 6.25% and decrement in anti-nutrient and anti-oxidant content. Addition of 30% pea flour to composite flour was found acceptable by considering the overall quality of the developed cookies and the economic aspect

Published by: Avanthika K., Dr. Meera M.

Author: Avanthika K.

Paper ID: V6I3-1675

Paper Status: published

Published: July 2, 2020

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