A research on formulation and evaluation chewing gum of Simvastatin
In the present era, many research and technological advancements are made in the field of oral drug delivery as it is highly accepted amongst patient. In this research the formulation of antihyperlipidemic chewing gum of simvastatin using water-insoluble gum base water-soluble other portion containing drug as well as excipients like taste masking agent sorbitol which use as a coating agent in this formulation. The primary and important requirement in the formulation of simvastatin chewing gum is the gum base, which gives it gummy texture for chewing action and as a drug vehicle.T his gum is isolated from the natural sources like a sapodilla moniker tree (Chiku) which fully grow in the Maharashtra region. This gum base has a property as like other gum bases which are present in nature. For the improvement in the stability of that gum base, which is converted in the dry form by drying and adding filler as talc and emulsifier such lecithin which was freshly collected from egg yolk. By drying this mixture further it converts in a directly compressible gum base powder, which possesses all-important flow property which requires for direct compression. Direct compression is one of the best methods as compared to the molding method in the formulation of chewing gum. For direct compression in directly compressible gum require other additional excipients like antiadherant, anti-caking agent, lubricant, antioxidant, flavor, and sweetening, the coating agent (sorbitol). For evaluation of formulated chewing gum, all parameter is same as like tablet except in-vitro drug release performance. For this purpose, the disintegration apparatus was modified in such way that it continuously compress or crush the chewing gum as like our mastication activity in the mouth, resulting in releases of the drug in the salivary fluid and absorbance were calculate on UV-visible spectra. In this also study the effect of stroke & distance between jaws which gives the valuable information about drug release performance in various ages patient.
Published by: Somnath Raosaheb Thanage, Dr. Bhawar Sanjay B., Dr. Dighe Santosh
Author: Somnath Raosaheb Thanage
Paper ID: V4I4-1243
Paper Status: published
Published: July 23, 2018
Minimization of artifacts in wrist pulse signals using signal processing techniques
Pulse pressure is a manifestation of arterial palpation of the heartbeat. Wrist pulse signal contains important information about the health status of a person and pulse signal diagnosis has been employed in oriental medicine for a very long time. This paper mainly addresses the problem of removing artifacts from wrist pulse signals. Noise is an irregular function that accompanies a transmitted electrical signal and tends to obscure it. The collected wrist pulse signals contain noise. The type of noise which the signal contains may be random noise, structured noise or physiological interference. In our paper, we have employed signal processing techniques in order to remove noise from the wrist pulse signal. Low Pass Filter (LPF) and Wavelet Transform (WT) techniques are used for this purpose. In our work, we have considered simulation and actual cases. In simulation cases, we have added noise to the signal and tried to remove it. In actual cases, we have considered the results of the simulation and implemented the signal processing techniques on actual noisy wrist pulse signals. Our work has studied the efficacy of LPF and WT techniques in minimizing artifacts in wrist pulse signals in simulation and in actual cases. Calculated mean square error for a simulated signal show that wavelet denoising has lesser mean square error than low pass filtering. Hence we have concluded that wavelet denoising is a better filtering than low pass filter.
Published by: B Shreyas, Abhishek M R, S Hema Priyadarshini, Dr. Anand Prem Rajan
Author: B Shreyas
Paper ID: V4I4-1281
Paper Status: published
Published: July 23, 2018
A study on geopolymer concrete with fly ash
The use of Portland cement in concrete construction is under critical review due to a high amount of carbon dioxide gas released to the atmosphere during the production of cement. From few years, attempts to increase the utilization of fly ash to partially replace the use of Portland cement in concrete are gathering momentum. Geopolymer concrete is a ‘new’ material that does not need the presence of Portland cement as a binder. Instead, the source of materials such as fly ash, metakaolin that are rich in Silicon (Si) and Aluminium (Al) are activated by alkaline liquids to produce the binder. Hence concrete with no Portland cement. This study reports the details of the development of the process of making low calcium based fly ash and Metakaolin-based geopolymer concrete. In the present experimental study, attempts are made to study on the various strength properties like compressive strength, split tensile strength, an also durability properties like initial surface absorption test on Geopolymer concrete made up of fly ash and Metakaolin. ISAT test was held on long-term durability properties of Geopolymer concrete. Experiments were conducted on Geopolymer Concrete with different percentages of metakaolin and molarity of alkaline activator. Studies were made on the residual compressive strength of Geopolymer Concrete mixes. It was observed that as the addition of Metakaolin to control the concrete mix of fly ash increases, the workability of the concrete mix was found to decrease as compared to Fly ash based control mix. It is observed from the experimental results and its analysis, that compressive and splitting tensile strength of geopolymer concrete increases with using high molarity NaOH solution and 25 to 50 percent Metakaolin. The replacement of fly ash up to this percentage shows 10 to 12% increment in Compressive strength and 28 to 34% increment in the split tensile strength of geopolymer concrete at 28 and 90 days respective
Published by: Digvijay Singh, Sherin Felix
Author: Digvijay Singh
Paper ID: V4I4-1312
Paper Status: published
Published: July 23, 2018
Strength and durability characteristics of concrete with steel fiber
With the improvement and modernization of societies, a lot of production activities are seen everywhere. These construction activities are increasing at a faster charge by way of large quantity. Also, the destruction of present structures, which have reached their provider lifestyles, runs parallel to the construction sports. It isn't crucial that the structures need to be demolished most effective after they have completed their carrier lifestyles, however also due to exchange in style and the ongoing trend of reconstruction of even healthful structures just for developing the greater area on the way to meet the prevailing demand. All such sports are producing waste in bulk, and this waste is called the Construction and Demolition (C&D) waste. Disposal of such C&D waste in a sustainable manner is a difficult nut to crack for the developers, developers, and owners. While the disposal of C&D waste is an undertaking, on the other hand, there is a severe shortage of obviously to be had aggregates for production of systems. Reduction of this call for in a small way is feasible with the recycling or reusing of creation and demolition waste generated from the development of sports. Hence, the recycling of demolished waste is a sustainable solution for C& D waste. The recycled concrete mixture has restricted utility as fill and subgrade fabric below the basis of systems, pavement, and many others. Those packages are non-structural applications. However, research has been ongoing all around the globe mainly in Japan, China, European nations and a few a part of India also, from final 50 years so one can find the ability implement of recycled aggregates as a structural grade concrete. The studies work on “A Study on Development of Steel Fiber Concrete made with RAC” is offered right here and is one such try to establish the RAC as a structural grade concrete. These studies work awareness on especially four structural properties of concrete i.E. Compressive Strength, Split Tensile Strength, and Durability. In this gift look at the experimental element is split into two exclusive series viz. Series-A (without fibers concrete blend) and Series-B (1% with the aid of extent Steel fibers in the concrete mix). The natural coarse aggregates are changed with Recycled coarse aggregates at one-of-a-kind substitute ratios. Four substitute ratios are considered in this gift take a look at zero% (manage specimens), 25%, 50% and a hundred%.
Published by: Jitendra Singh Yadav, Sherin Felix
Author: Jitendra Singh Yadav
Paper ID: V4I4-1310
Paper Status: published
Published: July 23, 2018
“White rusting of rocks”– The phenomena observed at Lonar crater lake
Abstract For the first time, white rusting/white coating of Silica on basaltic rocks has been observed at Lonar Crater Lake. Silica coating has been observed on basaltic rocks of Kilauea flow in Ka’u Desert on Hawaiian volcanic islands and has also been observed on the surface of Mars at Gusev Crater. The term white rusting/white coating of silica has been used for the same feature i.e., silica coating. White rusting /white coating phenomena observed on basaltic rocks of Lonar Crater Lake shows similarity to the silica coating observed on basaltic rocks of Kilauea flow in Ka’u Desert. Representative rock samples covered by white layer/white coating/white rusting were collected and after removal of the white-coated part were analyzed by XRF, showed that major oxide component was Silica (SiO₂) – 95-97 % mass of amorphous nature with minor quantities of SO₃, Fe₂O₃, Al₂O₃, CaO, and Cr₂O₃. The oxide content detected in white coating component at Lonar and that detected in silica coating on basaltic rocks of Kilauea flow in Ka’u Desert of Hawaiian volcanic islands shows good agreement which infers that similar process or unknown process may be operating at Lonar Crater Lake. From the studies carried by different researchers on silica coating on basaltic rocks of volcanic origin, it infers that the formation of white rusting at Lonar crater lake may be related to volcanic eruption or weathering conditions or physical changes due to climatic conditions existing at Lonar from the time the lake was formed. The white rusting is known to be a polymorph of silica in which SiO₂ value is found to be 95 – 97 mass %. This paper reports the first-hand information of observations and findings of white rusting/ white layer coating phenomena on basaltic rocks at Lonar Crater Lake on a preliminary basis and to put on record the works carried out regarding white coating phenomena with respect to silica coating on basaltic rocks of Kilauea flows in Ka’u Desert on Hawaiian volcanic islands.
Published by: Jadhav Raju D, Mali Harishchandra B.
Author: Jadhav Raju D
Paper ID: V4I4-1278
Paper Status: published
Published: July 23, 2018
A study to determine the impact of emerging online shopping sites on conventional model of buying and selling with reference to Pune city
This study attempts to focus on the impact of emerging online shopping sites on the conventional model of buying and selling with reference to Pune City. Retailers involve a large segment of the population and a large population is reliant on these retailers. However, the entrance of online shopping sites which have attractive incentives and wide-ranging varieties have put the conventional stores in an adverse situation. This research studies the preference of customers and their attitudes towards online and in-store shopping in various age brackets and also the reasons for doing so. This research also studies the different aspects of conventional retail businesses are affected and the different recovery mechanisms used by them to counter the online shopping sites in their survival race. This study also tries to cover the customer’s viewpoint on purchasing online or in conventional stores which are being preferred by them.
Published by: Vaishalli Nikalje
Author: Vaishalli Nikalje
Paper ID: V4I4-1313
Paper Status: published
Published: July 23, 2018
