To assess the explanatory model and perceived burden of child and adolescent psychiatric disorder and to study the relationship between them. Observation design was used. Computerized simple random technique was used to recruit 200 subjects after consent. Short explanatory model interview (SEMI) was used to assess the explanatory model and the family intervention burden scale was used to rate the burden of primary care givers. Among 200 subjects, 53.5% and 50.5% have medical model and non medical model respectively. Among the medical model 46.5% have allopathic perspective and 54.5% have complementary and alternative medicine model. Mean burden of primary care giver was 18.86 with SD ±11.08. There is a significant relationship between explanatory model and perceived burden of primary care givers (P=0.025). Assessing and understanding the influence of explanatory model on burden helps in intervening with burden of the primary care givers. Education and support are an essential part of nursing care. It is an effective method for improving the knowledge as well as decreasing burden of child and adolescent psychiatric disorders among primary care givers and will help in increasing adherence to therapeutic regimen.