The prediction of inelastic seismic responses and the evaluation of seismic performance of a building structure are very important subjects in performance-based seismic design. The seismic performances of reinforced-concrete buildings evaluated by nonlinear static analysis (pushover analysis) and nonlinear time history analysis are compared in this research. A finite element model that can accurately simulate the nonlinear behavior of building is formulated by considering several important effects such as p-delta can be considered rigid zones with joint failure due to the poor detailing of joints. Both global responses such as system ductility demand and local response such as inter-story drift are investigated in this research. A numerical example is performed on a 20-story reinforced concrete building in ZONE V. Finally, the global and local responses obtained from the pushover analysis are compared with those obtained from the nonlinear dynamic analysis of MDOF system. The results show that the PA is accurate enough for practical applications in seismic performance evaluation when compared with the nonlinear dynamic analysis of MDOF system.