Novel methods of dyeing has been introduced to get better results as compared to conventional dyeing. The present study was carried out for dyeing cellulosic fabric using bi-functional reactive dye and analysing the dye fixing ability of the reactive dyeing in presence of Tetracycline 250mg. The results were compared with the conventional dyeing methods. It is observed that the dye fixing in presence of pharmaceutical drugs gives better results as compared to conventional dyeing. Tetracycline is a group of broad-spectrum antibiotics whose general usefulness has been reduced with the onset of antibiotic resistance. The tetracycline consists of polycyclic ring with different side chain and a broad spectrum class of antibiotics against aerobes and anaerobes. Tetracycline’s are primarily bacteriostatic and exert their antimicrobial effect by inhibition of protein synthesis. Tetracycline is about 65% bound to plasma protein. The protein binding for intermediate and long lasting analogy is usually greater. Tetracycline is slightly soluble in water, freely soluble in acid and alkali, sparingly soluble in alcohol. Tetracycline is used to treat a wide variety of infections, including acne. It is an antibiotic that works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infectionsTetracycline can also be used in combination with anti-ulcer medications to treat certain types of stomach ulcers. Tetracycline is a yellow, odorless, crystalline powder. Tetracycline is stable in air but exposure to strong sunlight causes it to darken. Its potency is affected in solutions of pH below 2 and is rapidly destroyed by alkali hydroxide solutions. The work depicts a successful attempt to provide antimicrobial finish to the cotton fabric with outdated Tetracycline drugs. This method of unused medicines valorisation can solve two major environmental and economic problems: limitation of environmental pollution with pharmaceutically active compounds and reduction of the disposal costs of expired drugs.