Adolescence is most important stage of human life, particularly in adolescent girls as it lays down the conditions for healthy and safe procreation. Many girls face problems in their menstrual cycle including dysmenorrhea, which has figured less in past research studies. To find out the prevalence of dysmenorrhea among adolescent school girls, to determine the association between the dysmenorrhea and quality of life as well as with other selected variables. A cross-sectional study was conducted on 378 adolescent Senior Secondary School girls of 13-18 years of age, selected through multistage sampling technique using structured pretested questionnaire. The data was computed and analyzed in SPSS 23 version. Results: The prevalence of dysmenorrhea was 65.3%. Most of the students were in the age group of 15-16 years. The mean age of respondents was 15.26±1.293 years while it was 13.41±.682 for menarche. The most common symptoms reported were backache in 66.7% and irritability in 40.7% of the cases. The study found positive association between dysmenorrhea and family history and fruit intake. Dysmenorrhea was also found related with school absenteeism, poor exam grades, poor interpersonal relationship, decreased concentration in class and day-to-day activity. The prevalence of dysmenorrhea among adolescent girls was relatively high. The pain suffered could be severe that affected school absenteeism, social and academic performance and day-to-day activities. Association of dysmenorrhea was found to be significantly associated with age of menarche while it was highly significant with family history and fruits.