Quality assurance and control is the activity of providing the evidence needed to establish confidence among all concerned, that the quality-related activities are being performed effectively. Many quality assurance and control activities provide protection against quality problems through early warnings of troubles ahead It establishes a system of policies, procedures, and guidelines that establishes and maintains specified standards of product quality. One of the crucial determent in the successful implementation of TQM is Quality assurance. MSMEs play a critical role in the economic development of a country. Quality management of these MSMEs is would be critical for their stability. The aim of the paper is to examine the level of Quality assurance against product reliability at MSMEs of Ballari, Karnataka. The universe comprised executive and a non-executive workforce of the firm. Sampling was carried out using a convenient sampling technique with a sample size of 50 in line with the Cochran formula. Data was collected using observation and informal interview methods. Descriptive statistics and the Chi-square test was used to analyze the data. The research envisaged that all the factors of Quality assurance are associated with product reliability at the MSMEs. The study revealed that the quality manual and job instruction manual at the MSMEs has a significant influence on product reliability.