Siddha system is one of the oldest medical systems in the world. Siddhars, the fore-runners of this medical system served the community with many special therapies and Varmam is one among them. Varmam is the vital life energy points located in the human body. 108 main points have been identified by the Siddhars. The term Varmam also indicates the therapeutic manipulation of specific points in which the pranic energy is found concentrated. Even though Varmam therapy has been in existence for centuries, research in Varmam is still in the toddler stage. Central Council for Research in Siddha has the mandate to do research in Varmam. Standardization is the foremost component in any research. There are no specific guidelines to standardize the Varmam therapy. Just as a therapeutic interventional pre-clinical study, the standardization of Varmam is considered a pre-clinical one. Standardization of Varmam is comprised of mapping of Varmam points, the establishment of a relationship with Nadi, standardization of pressure given to Varmam points, standardization of techniques of applying pressure, physiological correlation of Varmam, standardization with respect to bioenergy field and therapeutic grouping of Varmam points. This paper deals with the research perspective of Varmam.