The aim of this paper is to determine the effect of Benzydamine in addition to normal saline mouthwash and compare it with normal saline mouthwash only, in reducing radiation/chemoirradiation induced oral mucositis in patients with Head and Neck malignancies. An open-label single-blind randomized controlled trial was conducted. Arm A - Radiotherapy/ Chemoirradiation who were randomized to receive Benzydamine mouth wash and normal saline mouth wash. Arm B - Radiotherapy/Chemoirradiation who were randomized to receive normal saline mouthwash only. Forty patients were accrued in the trial, 20 in the control arm and 20 in study arm. All patients completed the treatment protocol except 4 patients in the control group who discontinued treatment after 4 to 5 weeks. A number of patients in control vs. study arm of Chemo irradiation group were 14 vs. 13 and in Radiotherapy group 6 vs. 7 patients. The occurrence of Grade 3 mucositis was less in the control arm 30% vs. 40% but the onset was later among patients in the study arm (week 3). In the Chemo irradiation group requirement for analgesic (92.8% vs. 53.8%), topical anaesthetic (35.7% vs. 7.6% - significant), occurrence of mouth pain (28.5% vs. 15.3%) and Ryles tube feeding (28.5%vs15.3%) were less in the study arm and also tolerated more number of cycles of concurrent chemotherapy (76% vs. 14% p= 0.036). A number of patients having a break in treatment (0% vs. 42.8% -significant) and occurrence of oral thrush (16% vs. 28.5%) were more in study arm of Radiotherapy only group but the number of patients included was small (6 vs. 7). Nausea and vomiting was the predominant complaint in study arm probably induced by the study mouth wash. The occurrence of dryness of oral mucosa and throat was more in study arm of the chemo-irradiation group but less in radiotherapy only group. Overall the addition of Benzydamine mouth wash to normal saline mouthwash along with oral care protocol during treatment did not show significant benefit. But there seems to be some benefit with the use of study mouth wash in the chemo-irradiation group only. Since the sample size is small will need to do the study with larger numbers to document statistically significant benefit