The Covid-19 pandemic has deeply affected one’s mental as well as physical health. The front-line healthcare workers have been adversely impacted while having to work in a high-stress and trauma-exposed environment. They faced emotional and physical strain and the study attempts to understand the secondary traumatic stress in times of a global emergency and its impact on their subjective well-being. The researchers of the current study contended that secondary traumatic stress was inversely related to positive affect in frontline health care workers. A positive correlation was also expected between secondary traumatic stress and negative affect. This was studied among a sample of 200 front-line healthcare workers. The results of the current study provided significant evidence to support the proposed hypothesis. A highly significant regression was found between secondary traumatic stress and negative affect.