In this work I have proposed different network architectures using OPNET which consists of combination of ZigBee and WiMAX topologies. ZigBee is used to sense the data from the human body whereas WiMAX is used as a backbone to deliver the data at the distant location using microwave links. The nee of using WiMAX with ZigBee arises as ZigBee network’s coverage area is limited to few meters. This paper provides the layout architecture on the healthcare monitoring system developed using different combination of topologies of WiMAX and ZigBee in OPNET. The successful implementation of ZigBee-WiMAX based healthcare network depends upon the performance of the different proposed networks. In this paper the performance comparison is done between six different ZigBee-WiMAX topology combinations which include ZigBee mesh WiMAX mesh, ZigBee star WiMAX mesh, ZigBee tree WiMAX mesh, ZigBee mesh WiMAX Point to Multipoint (P2MP), ZigBee star WiMAX P2MP and ZigBee tree WiMAX P2MP topologies. Through simulations performed in OPNET, QoS parameters like throughput, load and delay have been evaluated to obtain the optimal performance of the proposed system based and to select best suitable topology combination out of the proposed network architectures.