Background: Trauma is still the leading cause of death in many regions of the world. Several severity scores have been developed to assist in the management of trauma victims. The Injury Control Centre in Uganda developed the Kampala Trauma Score (KTS II) for use in resource-limited settings. With the limitations of the existing trauma scoring systems, there is a need to explore new, affordable, easy to use accurate diagnostics. Some studies in high-income countries have shown that Serum Uric Acid (SUA) has been previously shown to be elevated in trauma and serves as an Alarmin. The aim of this study, therefore, was to determine the correlation between SUA levels and injury severity in trauma patients in a resource-limited setting. Methods: An analytical, single-center, cross-sectional study carried out at a tertiary hospital AE unit in Kampala. Trauma patients aged ≥18 years presenting within 24 hours after injury were recruited consecutively after obtaining a written informed consent. Injury severity was determined using the KTS II scoring system and venous blood was drawn for SUA assay. Data were analyzed and the correlation of SUA levels with severity of trauma as defined by KTS II was made. Results:  A total of 154 patients was recruited with a male to female ratio of 5.4: 1. Road traffic crashes (RTC) were the commonest (64%) cause of the injury; pedestrians were involved in 30% of the cases. The correlation between SUA levels and severity between injury was depicted by the area under the receiver operator characteristics curve = 0.6015. Conclusion: Serum uric acid was a poor prediction of severity of injury among trauma patients in this low resource environment.