Cholera disease appears to be a serious infections disease that bedeviled many locales, particularly in developing countries. A single case of cholera is a threat to neighboring areas and a global concern. The distribution of the disease is largely determined by series of environmental factors such as climate, local geography as well as living standards. Similarly, poor sanitation and hygiene are part of the drivers for the disease progression in most affected communities. Based on 10 years of data from the epidemiological unit, this study undertook the spatial analysis of cholera disease incidences in the Damaturu Local government area so as to determine the hotspots of the disease in the area and awareness of the disease among people. Also, six wards were purposively selected and questionnaires were administered to 381 household respondents. Descriptive statistics and GIS tools were used to analyze the data. Results were presented in maps and frequency tables. The findings reveal that there are three high vulnerable areas, five moderate areas, and three low-risk areas. The epidemic was concentrated in Nayinawa, Kukareta, and Maisandari wards. Nearest to the water body and high population density are factors that determine the spread of cholera disease in the study area. Further research is needed especially in the environmental factors influencing the occurrence of cholera in other to prevent and control future outbreaks and disasters.