The base isolation technique is one of the most widely used earthquake-resistant methods in designing structures. In this study, a G+15 RC structure is considered and modeled for the fixed base and isolated bases i.e., Lead Rubber Bearing (LRB) and High Damping Rubber Bearing (HDRB) using Etabs v19.1.0. The models are then analyzed and the seismic response of the structure is obtained by using equivalent static method and response spectrum method. The results, thus, obtained are compared and graphs of story displacement, story drift, storey shear, and storey acceleration are plotted for the fixed base and isolated bases. From this study, it is evident from the analysis that, the use of base isolation systems helps the structure from being majorly damaged, especially in higher seismic zones.