Background Self-medication is very common in our day to day life which is an unhealthy and risky practice. Present study was done to determine the knowledge, attitude and practice among 2nd Professional medical students of RIMS, Ranchi, Jharkhand. Material & Methods A questionnaire related to self-medication with consent was prepared and distributed among the students of 2nd Professional. Data was collected and analysed the results expressed as counts and percentages. Results Total 50 students participated in the study for taking self-medication and was no need to visit the doctor for minor illness. In maximum students, source of information of the drugs used for self-medication pharmacological based and learning process in the college. The source of drug was medical store. Most of the students took self-medication for loose motion & headache followed by cough, cold & fever. Out of total 50 students most of the students took paracetamol tablet as self-medication. Conclusion This study showed that third professional medical students after they studied pharmacological books they do not use any wrong medicine as self-medication. High level of awareness of 2nd Professional students has minimized self medication. Key words- Self-medication, Questionnaire, 2nd Professional.