Surgical site infections are the 3rd most common nosocomial infections in a hospital setting. It is a menace to both patients and surgeons, as it accounts for 1-3% of all surgical procedures, decreasing the success rate of surgeries. The study was conducted on 90 consecutive patients of Surgical site infection occurring after various surgical procedures within the same surgical team in the National Institute of Medical Sciences and Research, Jaipur, from 1st January 2018 till 30th June 2019. The objectives of this study were to assess the etiological factors of surgical site infection, the relationship of these factors with the type of surgical site infection, and to isolate the bacteria and the choice of antibiotic therapy suited for such patients. The rate of surgical site infections in our study was 6.99%. This value is relatively low when considering that the majority of the patients that were taken for surgery were in an emergency condition. A relationship was seen between co-morbidities in the form of diabetes mellitus, immunosuppressed patients, and patients who smoke, as all of them made up the majority of the patients who developed surgical site infection. As per treatment modalities, patients who had drains placed intra-operatively made up a larger majority of the total patients who had developed surgical site infections compared to those patients who did not have a drain placed. The most common bacteria isolated was Staphylococcus aureus which showed high sensitivity to piperacillin, vancomycin, linezolid, and amikacin.