Background: Traumatic brain injury (TBI) is a leading cause of illness, death, disability and socio-economic damage in India and other developing countries. Each year, approximately 1.5–1.7 million people are neurologically disabled due to TBI in India. Nurses are health professionals who see the full impact of TBI and have the skills to change a patient's recovery path. Nurses have a large role to play in the acute and chronic management of patients with moderate-to-severe TB because nurses are important members of interdisciplinary teams. Nurses have a lot of responsibilities in caring for these patients at all stages of treatment and recovery. Methods: The research approach adopted for the study was cross-sectional, exploratory design to determine nurses’ perceptions about care for patients with traumatic brain injury (TBI). As samples, 120 Staff nurses were selected through purposive sampling technique at PESIMSR Hospital inkpad, Andhra Pradesh. The collected data were analysed by using descriptive and inferential statistics in terms of Frequencies, Percentage distribution and chi-square test. Results: majority of the samples were 26-30 years old, female, undergraduates, critical care nurses, had 2.1-5 years of working experience and had no specific training regarding TBI patient care. Majority of the nurses had moderate knowledge and high level of confidence on care of TBI patients. The perceived confidence of nurses at PESIMSR hospital on care of TBI patients was significantly higher than their perceived knowledge. Age, professional qualification and professional experience of nurses had significant association with their perceptions. Conclusion: Results of this study suggested enhancing the knowledge of critical care and emergency room nurses through additional education and training on evidence-based TBI care.