21st century is the world full of synthetics and everyone are living in the influence of synthetic substances. Altered life styles, food habits and irregular sleep pattern had resulted not only Non communicable disease but also resulting in reduced immunity and is risking the person more for infections. Pharma Industry has grown as big as hierarchy in recent centauries and introduces new chemical molecules quoting as capable for treating diabetes, hypertension etc. But bitter truth is prolonged usage these medications itself has adverse effect on liver and kidneys causes hepatotoxicity and nephrotoxicity or organs specific toxicity. Development of Anti hypertensive medicine and anti diabetic drugs is considered to be a boon in the management of the respective diseases and safety evaluation of the same medicines are shown as lifesaving. But one has forgotten that these medicines are not given for a specific day but they are taken for longer duration and eve more than 20-30 years and threat a serious complications to the body organs and was not highlighted in previous decade.