As very earlier it has been discussed that Nitric Oxide are basic requirement of human life, hence it is our prime duty to save them to avoid the disturbance of biological system .This molecule is involved in the regulation of plant growth and development ,pathogens defense and abiotic stress responses .NO is rapidly induced potent plant growth regulator .In the present work the compounds were synthesized by transition elements of VI group using different standard procedures and carried out to study the effect on biological system. As a result it was found that some transition elements are very useful to prevent the infectious disease